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Liquorice

From Wikipedia, the free encyclopedia
(Redirected from Glycyrrhiza glabra)

For the confection, see Liquorice (confectionery). For other uses, see Liquorice (disambiguation).
Not to be confused with Lycoris, a distinct group of plants, some toxic.
Not to be confused with Licorice-root, an unrelated genus of plants.

Liquorice
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Fabales
Family: Fabaceae
Subfamily: Faboideae
Clade: Inverted repeat-lacking clade
Genus: Glycyrrhiza
Species:
G. glabra
Binomial name
Glycyrrhiza glabra
Synonyms[2][3][4]
  • Glycyrrhiza brachycarpa (Boiss.)
  • Glycyrrhiza glandulifera Waldst. & Kit.)
  • Glycyrrhiza hirsuta (Pall.)
  • Glycyrrhiza pallida (Boiss.)
  • Glycyrrhiza violacea (Boiss.)

Liquorice (Commonwealth English) or licorice (American English; see spelling differences; IPA: /ˈlɪkərɪʃ, -ɪs/ LIK-ər-ish, -⁠iss)[5][6] is the common name of Glycyrrhiza glabra, a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring is extracted.[7]

The liquorice plant is an herbaceous perennial legume native to West Asia, North Africa, and Southern Europe.[1] Liquorice is used as a flavouring in confectionery, tobacco, beverages, and pharmaceuticals, and is marketed as a dietary supplement.[7][8]

Liquorice extracts have been used in herbalism and traditional medicine.[7] Excessive consumption of liquorice (more than 2 mg/kg [3.2×10−5 oz/lb] per day of pure glycyrrhizinic acid, a key component of liquorice) can lead to undesirable consequences. Clinically, it is suspected that overindulgence in liquorice may manifest as unexplained hypertension, low blood potassium levels (hypokalemia), and muscle weakness in individuals.[7][8][9] Consuming liquorice should be avoided during pregnancy.[8]

Etymology

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The word liquorice, or licorice, is derived via the Anglo-French lycorys, from Late Latin liquiritia,[10] itself ultimately derived from Greek γλυκύρριζα, glykyrrhiza (the Modern Greek spelling of the genus is γλυκόριζα, glykoriza)[11] literally meaning 'sweet root' and referring to Glycyrrhiza glabra.[12]

The latter gives the plant binomial name with glabra meaning smooth[13] and referring to the plant's smooth husks; the former came to being via the influence of liquere, 'to become fluid', reflecting the method of extracting the sweet component from the roots.[14]

As of 2021, its English common name is spelled 'liquorice' in most of the Commonwealth, but 'licorice' is also used in some countries.[7][15][16]

Description

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Liquorice is a herbaceous perennial, growing to 1 metre (40 in) in height, with pinnate leaves about 7–15 cm (3–6 in) long, with 9–17 leaflets. The flowers are 8–12 mm (5⁄16–1⁄2 in) long, purple to pale whitish blue, produced in a loose inflorescence. The fruit is an oblong pod, 20–30 mm (3⁄4–1+1⁄8 in) long, containing several seeds.[17] The roots are stoloniferous.[18]

Chemistry

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Much of the sweetness in liquorice comes from glycyrrhizin.
Sections of liquorice root

Liquorice root contains triterpenoids, polyphenols, and polysaccharides.[8] Flavonoids account for the yellow root color.[8] The principal glycoside, glycyrrhizin, exists in content of 7% to 10%, depending on cultivation practices.[8] The isoflavene glabrene and the isoflavane glabridin, found in the roots of liquorice, are phytoestrogens.[19][20]

The scent of liquorice root comes from a complex and variable combination of compounds, of which anethole is some 3% of total volatiles.[citation needed] Much of the sweetness in liquorice comes from glycyrrhizin, which has 30–50 times the sweetness of sugar.[citation needed] The sweetness is different from sugar, being less instant, tart, and lasting longer.

Cultivation and uses

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Liquorice grows best in well-drained soils in deep valleys with full sun. It is harvested in the autumn two to three years after planting.[17] Countries producing liquorice include Turkey, Greece, Iran, and Iraq.[8]

Tobacco

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Liquorice is used as a flavouring agent for tobacco, for flavour-enhancing and moistening agents in the manufacture of American blend cigarettes, moist snuff, chewing tobacco, and pipe tobacco.[7][8][21] Liquorice provides tobacco products with a natural sweetness and a distinctive flavour that blends readily with the natural and imitation flavouring components employed in the tobacco industry.[8] Liquorice can also be added to cigarette rolling papers. As of 2009, the US Food and Drug Administration banned the use of any "characterizing flavors" other than menthol from cigarettes, but not other manufactured tobacco products.[22]

Food and confectionery

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See also: Liquorice (confectionery)
Dried sticks of liquorice root

Liquorice flavour is found in a wide variety of candies or sweets. In most of these candies, the taste is reinforced by aniseed oil so the actual content of liquorice is low.

In the Netherlands, liquorice confectionery (drop) is a common sweet sold in many forms. Mixing it with mint, menthol, aniseed, or laurel is common. It is also mixed with ammonium chloride (salmiak); salmiak liquorice in the Netherlands is known as zoute drop ('salty liquorice'). Strong, salty sweets are also consumed in Nordic countries where liquorice flavoured alcohols are sold, particularly in Denmark and Finland.[citation needed]

Dried sticks of the liquorice root are a traditional confectionery in the Netherlands as were they once in Britain. They were sold simply as sticks of zoethout ('sweet wood') to chew on as a candy.

Liquorice root chips

Pontefract in Yorkshire, England, is where liquorice mixed with sugar began to be used as a sweet in the contemporary way.[23] Pontefract cakes were originally made there.[24] In Cumbria, County Durham, Yorkshire and Lancashire, it is colloquially known as 'Spanish', supposedly because Spanish monks grew liquorice root at Rievaulx Abbey near Thirsk.[25]

In Italy, Spain and France, liquorice is used in its natural form. The root of the plant is simply harvested, washed, dried, and chewed as a mouth freshener. Throughout Italy, unsweetened liquorice is consumed in the form of small black pieces made only from 100% pure liquorice extract. In Calabria, a liqueur is made from pure liquorice extract and in Reggio Emilia a soft drink called acqua d'orcio is made. In some parts of the Arab world, including Syria, Egypt, and Palestine, it is consumed as a cold beverage, especially in Ramadan.[citation needed]

In southeastern Turkey, such as in Diyarbakır, licorice root is traditionally made into a chilled beverage that is most commonly consumed in summer.[26]

Research

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See also: Glycyrrhizin
See also: Enoxolone

Properties of glycyrrhizin are under preliminary research, such as for hepatitis C or topical treatment of psoriasis, but the low quality of studies as of 2017 prevents conclusions about efficacy and safety.[7][8][27]

Traditional medicine

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In traditional Chinese medicine, a related species G. uralensis (often translated as "liquorice") is known as gancao (Chinese: 甘草; lit. 'sweet grass'), and is believed to "harmonize" the ingredients in a formula.[28] although there is no high-quality clinical research to indicate it is safe or effective for any medicinal purpose. The European Medical Agency added liquorice to their list of herbal medicine.[29]

Fungicide

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The essential oils inhibit the growth of Aspergillus flavus.[30]

Adverse effects

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Consumption levels

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The United States Food and Drug Administration regards that foods containing liquorice and its derivatives (including glycyrrhizin) are generally recognized as safe for use as a food ingredient, if not consumed excessively.[7][8][9] Other jurisdictions have suggested no more than 100–200 mg (1.5–3.1 grains) of glycyrrhizin per day, the equivalent of about 70–150 g (2+1⁄2–5+1⁄4 oz) of liquorice confectionery.[9] Although liquorice is considered safe as a food ingredient, glycyrrhizin can cause serious side effects if consumed in large amounts (above 0.2 mg per kg per day).[7][8][9] One estimate is that a normal healthy person can consume 10 mg (0.15 grains) of glycyrrhizic acid per day.[31]

Because the composition of liquorice extracts in various products may exist in a broad range, there is not enough scientific information to determine that a specific level of intake is safe or unsafe.[7][8]

Physiological effects

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The effects of excessive liquorice consumption on lowering potassium levels in the blood and increasing blood pressure are a particular concern for people with hypertension (high blood pressure) or heart or kidney disease.[7]

Some adverse effects of liquorice consumed in amounts of 50 to 200 g per day over four weeks appear to be caused by glycyrrhizic acid (75 to 540 mg per day glycyrrhetinic acid) causing increases in blood pressure.[8] Consuming large amounts of liquorice during pregnancy has been associated with premature birth and health problems in the child.[8]

Hyper-mineralocorticosteroid syndrome can occur when the body retains sodium, and loses potassium, altering biochemical and hormonal regulation.[9] Some of these activities may include raised aldosterone levels, decline of the renin-angiotensin system and increased levels of the atrial natriuretic hormone in order to compensate the variations in homoeostasis.[9][32]

Other adverse effects may include electrolyte imbalance, edema, increased blood pressure, weight gain, heart problems, and weakness. Symptoms depend on the severity of toxicity. Some other complaints include fatigue, shortness of breath, kidney failure, and paralysis.[33][34]

Potential for toxicity

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The major dose-limiting toxicities of liquorice are corticosteroid in nature, because of the inhibitory effect that its chief active constituents, glycyrrhizin and enoxolone, have on cortisol degradation, and include edema, hypokalaemia, weight gain or loss, and hypertension.[8][9][35][36]

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  • Liquorice root with bark
    Liquorice root with bark
  • Inflorescence of G. glabra
    Inflorescence of G. glabra
  • Various liquorice products
    Various liquorice products
  • Different flavoured liquorice sticks
    Different flavoured liquorice sticks
  • Foliage
    Foliage
  • G. glabra from Koehler's Medicinal-Plants
    G. glabra from Koehler's Medicinal-Plants

References

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  1. ^ a b "Glycyrrhiza glabra". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 6 March 2008.
  2. ^ "The Plant List: A Working List of All Plant Species". Retrieved 2017-03-07.
  3. ^ "Glycyrrhiza pallida Boiss., Diagn. Pl. Orient. ser. 2, 2: 22 (1856)". The International Plant Names Index. Retrieved 2017-03-07.
  4. ^ "Glycyrrhiza violacea Boiss., Diagn. Pl. Orient. ser. 2, 2: 23 (1856)". The International Plant Names Index. Retrieved 2017-03-07.
  5. ^ "Liquorice". Dictionary.com Unabridged (Online). n.d.
  6. ^ "Licorice". Dictionary.com Unabridged (Online). n.d.
  7. ^ a b c d e f g h i j k "Licorice root". National Center for Complementary and Integrative Health, US National Institutes of Health. August 2020. Retrieved 11 June 2023.
  8. ^ a b c d e f g h i j k l m n o p "Licorice". Drugs.com. 31 January 2022. Retrieved 11 June 2023.
  9. ^ a b c d e f g Omar HR, Komarova I, El-Ghonemi M, Fathy A, Rashad R, Abdelmalak HD, Yerramadha MR, Ali Y, Helal E, Camporesi EM (August 2012). "Licorice abuse: time to send a warning message". Therapeutic Advances in Endocrinology and Metabolism. 3 (4): 125–38. doi:10.1177/2042018812454322. PMC 3498851. PMID 23185686.
  10. ^ Bradley H, ed. (1908). "Liquorice, licorice". A New English Dictionary On Historical Principles (NED). Vol. VI. L to N. Oxford, England: Clarendon Press. p. 332. Retrieved 2021-04-07.
  11. ^ "γλυκύρριζα". Epitome of the Kriaras Dictionary (online version) (in Greek). Center for the Greek Language. Portal for the greek language. Retrieved 2021-04-07.
  12. ^ γλυκύρριζα. Liddell, Henry George; Scott, Robert; A Greek–English Lexicon at the Perseus Project.
  13. ^ glabra. Charlton T. Lewis and Charles Short. A Latin Dictionary on Perseus Project.
  14. ^ Harper D. "Licorice". Online Etymology Dictionary.
  15. ^ "Liquorice". Merriam-Webster.com Dictionary. Merriam-Webster.
  16. ^ "Licorice". Merriam-Webster.com Dictionary. Merriam-Webster.
  17. ^ a b Huxley, A., ed. (1992). New RHS Dictionary of Gardening. ISBN 0-333-47494-5
  18. ^ Brown, D., ed. (1995). "The RHS encyclopedia of herbs and their uses". ISBN 1-4053-0059-0
  19. ^ Somjen D, Katzburg S, Vaya J, Kaye AM, Hendel D, Posner GH, Tamir S (2004). "Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues". The Journal of Steroid Biochemistry and Molecular Biology. 91 (4–5): 241–246. doi:10.1016/j.jsbmb.2004.04.008. PMID 15336701. S2CID 16238533.
  20. ^ Tamir S, Eizenberg M, Somjen D, Izrael S, Vaya J (2001). "Estrogen-like activity of glabrene and other constituents isolated from licorice root". The Journal of Steroid Biochemistry and Molecular Biology. 78 (3): 291–298. doi:10.1016/S0960-0760(01)00093-0. PMID 11595510. S2CID 40171833.
  21. ^ Erik Assadourian, Cigarette Production Drops Archived 2011-12-09 at the Wayback Machine, Vital Signs 2005, at 70.
  22. ^ "Flavored Tobacco". US Food and Drug Administration. 22 September 2009. Retrieved 21 December 2017.
  23. ^ "Right good food from the Ridings". AboutFood.com. 25 October 2007. Archived from the original on 7 June 2007.
  24. ^ "The strange story of Britain's oldest sweet". BBC Travel. 2019-07-11.
  25. ^ "Where Liquorice Roots Go Deep". Northern Echo. 13 September 2006. Retrieved 9 December 2008.
  26. ^ "Lemon, Licorice and Sumac Sherbet: Drinks to beat the Summer Heat". Mediterranean Observer. 22 August 2021. Archived from the original on 29 March 2023.
  27. ^ Yu JJ, Zhang CS, Coyle ME, Du Y, Zhang AL, Guo X, Xue CC, Lu C (2017). "Compound glycyrrhizin plus conventional therapy for psoriasis vulgaris: A systematic review and meta-analysis of randomized controlled trials". Current Medical Research and Opinion. 33 (2): 279–287. doi:10.1080/03007995.2016.1254605. PMID 27786567. S2CID 4394282.
  28. ^ Bensky D, et al. (2004). Chinese Herbal Medicine: Materia Medica, Third Edition. Eastland Press. ISBN 978-0-939616-42-8.
  29. ^ "Liquiritiae radix". European Medicines Agency. Retrieved 1 June 2021.
  30. ^ Mamedov NA, Egamberdieva D (2019). "Phytochemical Constituents and Pharmacological Effects of Licorice: A Review". Plant and Human Health, Volume 3. Cham: Springer Publishing. pp. 1–21. doi:10.1007/978-3-030-04408-4_1. ISBN 978-3-030-04407-7. S2CID 104427400.
  31. ^ Størmer F, Reistad R, Alexander J (1993). "Glycyrrhizic acid in liquorice—Evaluation of health hazard". Food and Chemical Toxicology. 31 (4): 303–312. doi:10.1016/0278-6915(93)90080-I. ISSN 0278-6915. PMID 8386690.
  32. ^ Mackenzie MA, Hoefnagels WH, Jansen RW, Benraad TJ, Kloppenborg PW (1990). "The Influence of Glycyrrhetinic Acid on Plasma Cortisol and Cortisone in Healthy Young Volunteers". The Journal of Clinical Endocrinology & Metabolism. 70 (6): 1637–1643. doi:10.1210/jcem-70-6-1637. ISSN 0021-972X. PMID 2161425.
  33. ^ Blachley JD, Knochel JP (1980). "Tobacco Chewer's Hypokalemia: Licorice Revisited". New England Journal of Medicine. 302 (14): 784–785. doi:10.1056/NEJM198004033021405. ISSN 0028-4793. PMID 6986557.
  34. ^ Toner JM, Ramsey LE (1985). "Liquorice can damage your health". Practitioner. 229 (1408): 858–860. PMID 4059165.
  35. ^ Olukoga A, Donaldson D (June 2000). "Liquorice and its health implications". The Journal of the Royal Society for the Promotion of Health. 120 (2): 83–9. doi:10.1177/146642400012000203. PMID 10944880. S2CID 39005138.
  36. ^ Armanini D, Fiore C, Mattarello MJ, Bielenberg J, Palermo M (September 2002). "History of the endocrine effects of licorice". Experimental and Clinical Endocrinology & Diabetes. 110 (6): 257–61. doi:10.1055/s-2002-34587. PMID 12373628.
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